SCREENING OF DRUG CANDIDATES AGAINST ENDOTHELIN-1 TO TREAT HYPERTENSION USING COMPUTATIONAL BASED APPROACHES: MOLECULAR DOCKING AND DYNAMICS SIMULATION.

Hypertension (HTN) is a major risk factor for cardiovascular and renal diseases, cerebrovascular accidents (CVA) and a prime underlying cause of worldwide morbidity and mortality.Hypertension is a complex condition and a strong interplay of multiple genetic, epigenetic and environmental factors is involved in its etiology.Previous studies showed an

The effects of a light-emitting diode (LED) were examined and compared to fluorescent light on the growth performance of four marine microalgae, Nannochloropsis oculata, Tetraselmis suecica, Chaetoceros calcitrans, and Thalassiosira weissflogii cultured under laboratory conditions for 240 h (10 days).The results showed that the cell densities of N.

Data allocation problem (DAP) is of great importance in distributed database systems (DDS).Minimizing the total cost of transactions and queries is the main objective of DAP which is mostly affected by the volume of transmitting data through the system.On the other hand, the volume of transmitting data depends on the fragment-to-site allocations me

Robots are becoming integral to society and industries due to their enormous advantages.Among the various categories of mobile robots, including wheeled robot, tracked robot, and legged robots, the latter stands out as a better choice for most field applications due to their adaptability across various terrains.The purpose of this review is to stud

Abstract Background Natural selection on fitness-related traits can be temporally heterogeneous among populations.As climate changes, understanding population-level responses is of scientific and practical importance.We examined 18 phenotypic traits associated with phenology, biomass, and ecophysiology in 403 individuals of natural Populus trichoca